主讲人: |
QIN Yixian(钦逸仙) |
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主 题: |
多孔介质和骨骼重建旳力生物学 |
时 间: |
2018-04-11 14:30 |
地 点: |
机械工程楼八层大会议室 |
[主讲人简介] |
Dr. Yi-Xian Qin is a Professor in the Department of Biomedical Engineering (BME), and Associate Dean of College of Engineering and Applied Sciences. He is also a Professor in Mechanical Engineering, Electrical and Computer Engineering, and Orthopaedics. His research has been focused on musculoskeletal tissue regeneration and translation through physical regulation and characterization of tissue quality, as well as evaluating the mechanisms responsible for tissue remodeling. His laboratory is currently interested in the areas of mechanobiology of bone tissue regeneration, mitigation of bone loss, and dynamic loading induced fluid flow in regulating bone remodeling and cellular activities. He also invented noninvasive ultrasound imaging and therapeutics for prevention of bone loss and fracture healing. He has published more than 100 peer-reviewed papers and 20+ books and book chapters in musculoskeletal research journals and books. He is Fellows of the American Institute of Medicine and Biological Engineering (AIMBE), and International Astronautics Academy (IAA).
钦逸仙,教授,纽约州立大学石溪分校,石溪大学生物医学工程系的创始人之一,同时也是机械工程,电子计算机工程和矫形学教授。现任肌骨生物力学实验室主任,同时担任工程与应用科学学院副院长。先后担任国际宇航科学院院士、美国医学与生物工程学会(AIMBE)会员,BMES 矫形外科康复工程学会年会主席,国际华人骨研学会(ICHTS)主席。在石溪大学主讲生物工程学导论、生物力学、计算生物力学及有限元方法等。钦教授发明了非侵入性超声成像和治疗方法来预防骨质流失和骨折愈合。已发表论文和参编论著共计100多篇,在组织工程和骨力学等相关领域拥有8项专利。 |
[内容简介] |
he mechanical environment defines the structure and function of almost every tissue in the human body, especially in bone, where mechanical loading has been known to mediate skeletal adaptation. Osteopenia, a condition of diminished bone mass, becomes osteoporosis when mechanical demands exceed the ability of the skeletal structure to support them, such as microgravity during long-term space mission. While poor bone quantity and quality are principal factors in osteoporosis, consequences of the disease are exacerbated by a functional and age-related decrease in muscle strength and postural stability, markedly increasing the risk of falling and injury. The potentials of mechanotransductive intervention within a unique integrated solid-fluid phase tissue and materials to promote regeneration and remodeling are still not fully understood. The Maurice A. Biot theory has defined the mechanical behavior in such biological tissues. Using theoretical, computational, cellular and animal models, my laboratory is focused on the areas of mechanobiology of bone tissue regeneration, mitigation of bone loss, and dynamic loading induced fluid flow in regulating bone remodeling and cellular activities. We also invented noninvasive ultrasound imaging and therapeutics for prevention of bone loss and fracture healing. Recent works in image-guided cellular and tissue response and bone regeneration will be presented.
机械环境定义了人体中几乎所有组织的结构和功能,特别是在骨骼中,机械负荷被认为可以调节骨骼的适应度。骨质疏松症是骨质疏松的一种情况,常发病于机械需求超过骨骼结构的能力时,例如在长期的太空任务中的微重力。骨质疏松症的后果是肌肉强度和体位稳定性的降低,从而加重了患骨质疏松症的风险。在一个独特的集成固液相组织和材料中促进再生和重建的机械转换潜力仍然存在研究的余地。Maurice A. Biot理论已经定义了这种生物组织中的机械行为。肌骨生物力学实验室的研究主要集中在骨组织再生的机械生物学领域的研究,减少骨丢失,借助动态负荷诱导的流体调节骨重塑和细胞活动。研究团队发明了非侵入性超声成像和治疗方法来预防骨质流失和骨折愈合,提出了借助图像引导细胞和组织反应进行骨再生。. |
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